Tottenham are set to face their next Premier League rivals Southampton on December 28 (2021).

Antonio Conte's side will be hoping to have another successful match following their 3 - 0 win over Crystal Palace at the weekend.

Spurs will be without Ryan Sessegnon and Cristian Romero due to injuries.

<strong>Ryan Sessegnon:</strong> muscle injury

<strong>Cristian Romero:</strong> hamstring injury


<h2>Tottenham Predicted Line Up vs Southampton</h2>


<img class=" wp-image-595070" src="https://www.vbetnews.com/uploads/2021/12/Spurs-vs-Southampton--1024x1024.jpg" alt="Tottenham predicted line up vs Southampton " width="513" height="910" /> <em>Tottenham possible starting XI vs Southampton</em>



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<h2 class="title"><a href="https://www.vbetnews.com/boxing-day-tottenham-3-0-crystal-palace/">Boxing Day: Tottenham 3-0 Crystal Palace</a></h2>

Hripsime Hayrapetyan

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