The big decisions of resting star players will not be affecting the Argentinian
Overplaying can lead to injury risks. That was the case with Sergio Busquets recently against Eibar. The Argentine wants to play every single minute for the club, and the manager would be the last person to stand on his way.
Except during his injury, he has played every other match possible, and has only been subbed off once, against Ajax with the game already decided.