Jesse Lingard was among four senior Manchester United stars absent from training on Monday.
Ashley Young was also missing, despite having started at right-back on Saturday. Ander Herrera and long-term injury absentee Marcos Rojo both missed out also.
But Antonio Valencia and Phil Jones, both of whom missed the loss to the Hammers, were both backs on the training field and are in contention for the return to European action.
United can take a major step towards the last 16 - even at such an early stage - with a victory over Marcelino's men at Old Trafford.
