After 22 year in charge Wenger is set to leave the Emirates stadium and will do battle with old foe Jose Mourinho one final time in the Premier League.
In contrast, Alexis Sanchez will face off against his former club for the first time following his January switch.
Sanchez has faced many difficulties since moving from United, but has found something like his best form recently, and was man of the match in last weekend's FA Cup semi-final win over Spurs.
Ahead of the match Arsenal manager has admitted Sanchez just needs to be adopted and he will soon find his best form after difficult start.
“We need seven points, we have a final to play. Can he help us?
“I hope so and next season after pre-season, after being comfortable and adapted he’s going to be great for us,” Wenger said.
Arsene Wenger: “Sanchez is going to be great for us”